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Atrofia Progresiva de Retina / Progressive Retinal Atrophy
PostPosted: Thu Jan 15, 2009 8:08 pm Reply with quote
Gio
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Arrow La Atrofia retinal progresiva, o PRA como se le llama comunmente, es un desorder hereditario.
El PRA es una enfermedad de la retina. Este tejido, localizado dentro de la parte trasera del ojo, contiene celulas especializadas llamadas fotoreceptores que absorben la luz enfocada en el lente del ojo y convierte la luz en seņales nerviosas electricas. Las seņales nerviosas de la retina pasan por el nervio optico al cerebro donde se persiven como vision. Los fotoreceptores de la retina se especializan inicialmente en barras, para vision en luz debil (nocturna) y en conos para vision con luz brillante (vision de dia y color).
El PRA afecta inicialmente las barras y luego los conos. En las familias humanas, la enfermedad equivalente a PRA (en perros) seria "Retinitis pigmentosa".

Temprano en la enfermedad, los perros afectados son ciegos en la noche, careciendo la capacidad de ajustar su vision a la luz debil; mas adelante falla su vision diurna. Conforme su vision deteriora, los perros se adaptaran a sus desventajas mientras su ambiente siga siendo constante y no se haga frente a situaciones que requieren de una buena vision. Conforme la enfermedad avanza las pupilas de sus ojos se dilatan cada vez mas, en un intento de recolectar mas luz, causando sensibilidad a la luz; la retina puede llegar a verse nublada u opaca, resultando en una catarata.

Arrow Progressive retinal atrophy, or PRA as it is frequently termed, is an hereditary, blinding disorder.
PRA is a disease of the retina. This tissue, located inside the back of the eye, contains specialized cells called photoreceptors that absorb the light focused on the eye's lens, and converts that light into electrical nerve signals. The nerve signals from the retina are passed by the optic nerve to the brain where they are perceived as vision. The retinal photoreceptors are specialized into rods, for vision in dim light (night vision), and cones for vision in bright light (day and color vision). PRA usually affects the rods initially, and then cones in later stages of the disease. In human families, the diseases equivalent to PRA (in dogs) are termed "Retinitis pigmentosa".

Early in the disease, affected dogs are nightblind, lacking the ability to adjust their vision to dim light; later their daytime vision also fails. As their vision deteriorates, affected dogs will adapt to their handicap as long as their environment remains constant, and they are not faced with situations requiring excellent vision. At the same time the pupils of their eyes become increasingly dilated, in a vain attempt to gather more light, causing a noticeable "shine" to their eyes; and the lens of their eyes may become cloudy, or opaque, resulting in a cataract.



Retina normal
Normal Retina


Retina con un nivel medio de PRA. La vascularidad ha sido reducida notablemente.
A mid-stage PRA retina. The vascularity has been markedly reduced.


Fotos por NetPets / Pictures by NetPets

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PostPosted: Fri Jan 16, 2009 3:54 am Reply with quote
Xolove
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Thank you for posting this Giovanna,

That's the disease my Bibi is suffering from.

I think it's also important to mention that it's a genetic disease that only happens if both parent dogs are carriers.
It's already a problem with some other breeds.
I know of this http://optigen.com/ company that's doing this kind of tests.
Dogs tested positive won't be excluded from breeding but they mustn't be bred to other carriers.


Gracias por poner este mensaje Giovanna,

Esta es la enfermedad que mi Bibi sufre.

Creo que es importante mencionar que es una enfermedad genetica que solo pasa si ambos padres son portadores.
Ya es un problema en algunas razas.
Se que esta compaņia http://optigen.com/, hace este tipo de examenes.
Los perros examinados que den positivo no seran excluidos de la crianza pero no deben criarse con otros portadores.
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PostPosted: Fri Jan 16, 2009 11:08 am Reply with quote
xoloitzcuintli
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PostPosted: Fri Jan 16, 2009 4:33 pm Reply with quote
Gio
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You are welcome Yu-Dong!
I've heard about Optigen and I think it's great that many breeders are testing their dogs to make sure they are healthy... unfortunately here there is no such test, some of us do check our dogs to avoid ceirtain diseases, but still is a minority.
Elida asks if dogs with PRA can get surgery to improve their vision?

De nada Yu-Dong!
He oido sobre Optigen y creo que es genial que muchos criadores esten examinando a sus perros para asegurarse que esten saludables... desafortunadamente aqui no hay ese examen, algunos de nosotros si checamos nuestros perros para evitar algunas enfermedades pero aun asi, es la minoria.
Elida pregunta si los perros con PRA pueden tener cirugia para mejorar su vision?


Hola Eli,
No estoy segura si se puede mejorar con operacion,deja investigo un poco mas y en cuanto sepa te digo.

Hi Eli,
I'm not sure if it can get better with a surgery, let me make a little more research and I'll let you know what I found out.


Arrow Yu-Dong nos comenta que es una enfermedad genetica que solo pasa si ambos padres son portadores, existe una compaņia llamada "Optigen" (www.optigen.com) que realiza test para descartar enfermedades oculares.
En Mexico esta prueba no se realiza, hay que ir a EUA para realizar la prueba con Optigen.
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PostPosted: Fri Jan 16, 2009 6:19 pm Reply with quote
Xolove
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Unfortunately affected dogs will go blind no matter what. This condition is not treatable.

They can go blind as early as 12 months or between the age of 3-6yrs.


Desafortunadamente los perros afectados quedaran ciegos no importa que. Esta condicion no es tratable.
Pueden quedarse ciegos tan pronto como a los 12 meses o entre los 3 y 6 aņos.

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PostPosted: Thu Jan 22, 2009 12:25 am Reply with quote
ARAEKALA
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segun se esta enfermedad no se puede operar, se hacen pruebas para saber si los perros son portadores en caso de que lo sean es recomendable no cruzar con otro ejemplar que padesca esta enfermedad, se hace un test que muestra si los perros tienen el egen que lo provoca o no, se puede hacer desde que los perros son cachorros.
estoy familiarizada con esta enfermedad por que es una de las mas comunes en el perro de aguas portugues raza que yo crio, y la operable es una enfermedad similar al desprendimiento de retina, que es comun en los perros que tienen contacto con el agua en especial los qu ese hechan clavados, tengo un libro sobre el perro de aguas portugues en cuanto regrese de la expo de torreon les agrego la informacion que vien ahi sobre esta enfermedad.
saludos


I believe this disease cant be operated, there are tests to know if dogs are carriers and if they are, it's recomended not to breed to other dog with the same disease, the test shows if the dogs have the gen that causes the disease or not, it can be done since the dogs are puppies.
I'm familiarized with this disease since it's one of the most common in the portuguese water dog, which I breed, the one that can be operated is similar to the retinal detachment, which is common in dogs that have contact with water, specialy the ones who dive into it, I have a book about the portuguese water dog, as soon as I come back from an expo in torreon I'll put some info that comes there about the disease.
Greetings
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PostPosted: Thu Jan 22, 2009 12:29 am Reply with quote
xoloitzcuintli
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PostPosted: Thu Jan 22, 2009 10:53 am Reply with quote
Gio
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Muchas gracias Arantza!

En EUA hay un lab llamado Optigen, ellos realizan estudios a diferentes razas (el xolo desafortunadamente no viene en su lista)... lo que ellos hacen es tomar una muestra de sangre.
Te dicen si tu perro es portador, esta enfermo o esta libre de la enfermedad.

Un portador se puede cruzar con un perro libre de esta enfermedad, el riesgo de que nazca uno enfermo es bajo pero es alto el riesgo de que nazcan portadores.

Aca en Mexico existe algun lugar que haga esa prueba?


Thanks a lot Arantza!

In EUA there's a lab called Otigen, that realize tests on different species (the xolo unfortunatedly is not on their list).. what they do is take a blood sample. They tell you if your dog is a just a carrer, if it's sick or if it's free of the disease.

A carrier can be bred to a dog who is free of this desease, the risk of a sick puppy is low but the risk of carrier puppies is high, is there any place in mexico that makes that test?
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PostPosted: Thu Jan 22, 2009 12:29 pm Reply with quote
ARAEKALA
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no yo mando hacer la prueba a USA
tengo una la escaneare tan pronto regrese a queretaro para mostrarles como es, hay dos laboratorios de optigen en america uno en USA y otro en brasil, pero se les puede mandar la muestra por paqueteria, auqnue la UNAM tiene un prueba similar aun esta en proceso no es igual a la de Optigen pero si funcional


no, I send the test to the ISA I have one, I'll scan it as soon as I go back to queretaro to show us how it is, there are two labs of optigen in america, one in USA and other in Brazil, but you can send a sample by packaging, although the UNAM has a similar test still in process, it's not the same as the optigen, but it works!
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PostPosted: Thu Jan 22, 2009 12:32 pm Reply with quote
ARAEKALA
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aqui esta el articulo en ingles regresando lo pongo en espaņol

Here's the article in english, I'll put it in spanish when I come back
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PostPosted: Thu Jan 22, 2009 1:09 pm Reply with quote
ARAEKALA
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progressive retinal atrophy (pra)
is a genetic desease that causes a late onset slowly progressive loss of sight in portuguese water dog. this desease is present in many other breeds, with varying ages of onset and rates of preogression. In the PWD can present clinically to the owner as as early as 14 months of age. Affected dogs will first show signs of difficulty seeing at night or in dim light. This progress to total blindness, although some dogs affected latter in life can retain limited vision (light/dark discrimination). There are affected dogs ten years of age who are not experiencing noticieable difficulties in their degree of visual acuity. The age of onset, progression and severity of the visual deficit can vary within litters.
progresisve retinal atrophy in PWD is caused by a simple autosomal recessive gene. Affected dogs recive the defective gene from bouth prents, who are carriers. Carriers of the defective gene are normal in all aspects except for their hability to pass teh defective gene to approximately half of their offspring.
PRA can be diagnosed by a board-certified veterinary ophthalmologist during a direct ophthakmoscopic examination which can also be referred to as a CERF exam). CERF is teh Canine Eye Registry Foundation, a national database of canine eye dessease. There are afected dogs who had normal CERF examination at six years of age. An electrogram (ERG) can identify afected dogs earlier than CERF exam. this can be performed ata limited number of veterinary facilities in USA, and it requires general anesthesia. At this time expert feels that 99% of afected PWD can be identified by two yearss of age by specific techniques of electroretinography.
a direct oftalmoloscopic or electroretinogram examination can identified only afected dogs. There is presently no clinical test to identify carriers of PRA (those dogs with one defective gene for the disease). The only way to identify a dog as a carrier of PRA is if is (1) produced an offspring with PRA or (2) if an offspring of an affected dog.
to identify a dog statiscally as a carrier or non carrier of the defective gene, a test mating can be performed by breeding to an affected dog with PRA.
if a minimum of seven offspring have normal ERG examinations at minimum of 2 years of age then the tasted parent is statiscally clear of being a carrier of PRA with greater than 99 percent of confidence.
Because of the need to follow offspring for a minimum pf 2 years the expiriance of ERG testing and the emotional toll of breeding and placing puppies who may go blind into pet homes, test mating is not an option for many breeders.
Presently tthe only way to find a dogs risk of being a carrier or affected with PRA is throught a relative risk of pedigree analysis.
is currently recomended have an annual direct ophtalmoscopic examination by board certificated veterinary ophtalmologist. Remmember a normal CERT or ERG shows only thata particular dog i not affected at the time of the examination. It proves nothing abou the posible carrier status of the dog. Breeders should attempt to breed to breed dogs whose carrier status is lower than the average of the breed. Highly recomended breed with tested dogs.

aqui esta extraido del libro the new complete portuguese wather dog, se aplica a todas las razas, se remarca en el perro de aguas protugues por que esuna raza que la padece mucho. espeor le sirva vuelvo hasta el lunes ojala alguien se adelante y lo traduzca.
ara
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PostPosted: Thu Jan 22, 2009 2:38 pm Reply with quote
Gabriel Mestre
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Hi Yu-Dong, Hola a todos,

Some body knows how big this disease within the xolo breed?

Alguien sabe que tan grande es este padecimiento al interior de la rza xoloitzcuintle?

Saludos

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PostPosted: Mon Aug 24, 2009 7:45 am Reply with quote
xoloaus
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Can anyone suggest Canine Eye Tests for the Xolo Breed? I have my two booked in to see a Canine Opthanmologist and she can only do a basic eye test, unless the Xolo breed is known to carry a specific problem that she can test for?
Does anyone know of any tests that SHOULD be done ?

Many Thanks
Jacqi
West Australia

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PostPosted: Mon Aug 24, 2009 2:50 pm Reply with quote
Gio
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Hi Jacqi!!
In the US there's a lab named Optigen, it does blood exams to determine if the dogs has a disease, is a carrier or is free. But the problem is that right now Us doesn't allow the entrance of blood samples.
Let me investigate about this and other exams, and I'll let you know right away!

Hugs,
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PostPosted: Sat Dec 26, 2009 2:10 am Reply with quote
xoloaus
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Hi Gio
Hope xmas went well for you all.Do you or any listers have any advice on Health Tests for Xolos? ( Apart from Hips and elbows) I am about to start testing and want to follow protocol in what breeders have tested for before.
Also is there a World database for results ?

Many Thanks

Jacqi Australia

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Atrofia Progresiva de Retina / Progressive Retinal Atrophy
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